THE HER2-DIRECTED ANTIBODY-DRUG CONJUGATE DHES0815A IN ADVANCED AND/OR METASTATIC BREAST CANCER: PRECLINICAL CHARACTERIZATION AND PHASE 1 TRIAL RESULTS

Abstract Approved antibody-drug conjugates (ADCs) for HER2-positive breast cancer include trastuzumab emtansine and trastuzumab deruxtecan.To develop a differentiated HER2 ADC, we chose an antibody that does not compete with trastuzumab or pertuzumab for binding, conjugated to a reduced potency PBD (pyrrolobenzodiazepine) dimer payload.PBDs are pot

To investigate the hypoglycemic effect and potential mechanism of pumpkin polysaccharides and puerarin on type II diabetes mellitus (T2DM) mice, mice were fed a high-fat diet and injected intraperitoneally with streptozotacin to induce T2DM.After eight weeks of drug administration, blood samples were withdrawn veuve ambal rose from tail veins of mi

Rachel Mills, Susanne B Haga Duke Center for Applied Genomics and Precision Medicine, Duke University Medical Center, Durham, NC, USA Introduction: Pharmacogenetic (PGx) testing is a leading application for personalized and precision medicine; however, there are barriers, including limited provider and patient understanding, which affect its uptake

AbstractMalignant atrophic papulosisis is a rare, multisystem obliterative majicontrast red vasculopathy of unknown etiology, occasionally involving the cranial nerve.We describe the first case of malignant atrophic papulosisis with cranial nerve and peripheral nerve involvement in China.A 47-year-old woman presented to our hospital with atrophic p